Five Ghanaian players suffered elimination with their clubs at the second qualifying round of the UEFA Europa League.
Striker Richard Gadze played the entire duration for FC Zira who drew 0-0 with Romanian side Astra and bowed out 3-1 on aggregate.
Anthony Annan lasted the entire duration and youngster Evans Mensah came on in the 73rd minute for HJK in their 1-1 draw at home with FK Shkendija.
HJK were eliminated after losing the first leg 3-1 in Macedonia.
Joel Fameyeh came on for the second half but could not help Belarussian side Dinamo Brest who lost 3-1 at home to Austrian side Rheindorf Altach.
Striker Francis Narh was handed a starting role and replaced after 57 minutes Levski Sofia who lost 2-1 at home to Croatian side Hajduk Split and suffer an overall 3-1 defeat.