In a repeat of last year’s final, which Erik ten Hag’s men won 2-0, both managers named much-changed sides at Old Trafford.
Manchester United’s defence of the League Cup came to a limp end in a 3-0 home defeat by Newcastle on Wednesday as Arsenal were well-beaten 3-1 at West Ham.
Liverpool overcame Bournemouth 2-1 to progress to the quarterfinals, while Chelsea saw off Championship side Blackburn 2-0.
In a repeat of last year’s final, which Erik ten Hag’s men won 2-0, both managers named much-changed sides at Old Trafford.
But it was Newcastle’s strength in depth that showed as United slumped to an eighth defeat in 15 games in all competitions this season – their worst start to any campaign since 1962/63.
Tino Livramento and Lewis Hall have had to wait for their chance to shine since signing for the Magpies but the young full-backs played a huge role as Eddie Howe’s side got revenge for defeat at Wembley in February.
Chelsea loanee Hall then volleyed home a brilliant effort from the edge of the box just eight minutes later.
Joe Willock’s solo run and stunning finish then drew the sting from any chance of a United fightback on the hour mark.
Arsenal manager Mikel Arteta was left to rue leaving Declan Rice out on his return to the London Stadium, with the England international alongside Bukayo Saka, Martin Odegaard and William Saliba on a star-studded Gunners’ bench.
Ben White beat Ramsdale to Bowen’s dangerous in-swinging corner but could only head into his own net after 16 minutes.
Mohammed Kudus made it 2-0 on 50 minutes with a brilliant touch and low finish from Nayef Aguerd’s long ball forward.
Rice was then introduced to a mixed response from the West Ham faithful.
But any hope of an Arsenal fightback was quashed by Bowen’s strike from the edge of the box that Ramsdale should have done better to keep out.
Odegaard grabbed a consolation deep into stoppage time, but it was too little, too late as Arsenal’s 30-year wait to win the League Cup goes on.
Liverpool had to see off a spirited effort from Bournemouth and appalling weather conditions as Storm Ciaran swept in at the Vitality Stadium.
Justin Kluivert had cancelled out Cody Gakpo’s opener with his first Bournemouth goal.
But Darwin Nunez came off the bench to win the tie with a spectacular dipping strike from outside the box.
Benoit Badiashile and Raheem Sterling were on target as Chelsea secured a rare home win under Mauricio Pochettino to reach the last eight.
Everton’s upturn in form continued with a comfortable 3-0 win over Burnley.
James Tarkowski, Amadou Onana and Ashley Young scored on the night the Toffees remembered former chairman Bill Kenwright, who died aged 78 last week.
Fulham avoided an upset against Championship high-flyers Ipswich.
Harry Wilson, Rodrigo Muniz and Tom Cairney were on target in a 3-1 win for Marco Silva’s men at Portman Road.
Middlesbrough and Port Vale secured their places in the quarterfinals with victories over Exeter and Mansfield respectively on Tuesday.